Long live generalism

Focusing on generalism.

Long live dynamic parameters!

In a recent article about pulse pressure variation (PPV), after 4 pages of physiologic explanations, Dr Sondergaard finally concluded that ‘the subject is an exceptional demonstration of physiology but hardly guides the management of critically ill patients’ [1]. If I agree with the first part of this statement (I and others spent years dissecting the complex physiology behind PPV), I strongly ...

Long Live Continuous Consensus

Fault-tolerant systems often require a means by which independent processes or processors can arrive at an exact mutual agreement of some kind. The work announced in this note studies the continuous consensus problem, which is a general tool for enabling actions that are performed at the same time at different sites of the system to be consistent with one another (e.g., mutual exlusion, firing ...

Live long and prosper.

In this issue of Molecular Pharmacology, Meyn et al. (p. 1320) provide the results of the first comprehensive investigation of the expression pattern of the Src family of nonreceptor tyrosine kinases (SFK) in mouse embryonic stem (ES) cells. They found that self-renewing ES cells express seven of the eight mammalian SFK members and that some undergo distinct expression changes during early diff...

Long live the pore

n the first in vivo characterization of nuclear pore complex (NPC) dynamics in mammalian cells, Daigle et al. (page 71; see also the Comment on page 17) have found that NPCs are remarkably stable complexes that appear to be anchored to a protein network in the nuclear envelope. The work also demonstrates the feasibility of tracking single protein complexes in living cells. By fusing GFP tags to...